Ook gespeeld op 4 dec 2021

• Undy Athletic – Cwmbran Celtic3–4
• Llantwit Major – Briton Ferry0–1
• Port Talbot Town – Swansea University0–2
• Llanrhaeadr – Prestatyn Town3–2
• Trefelin – Carmarthen Town0–2
• Llandudno – Guilsfield0–0
• Ruthin Town – Penrhyncoch5–1
• Holyhead Hotspur – Airbus UK1–2
• Llanidloes Town – Holywell1–1

Eerdere ontmoetingen

2 eerdere duels: Bangor City won 1, 0 gelijk, Buckley Town won 1.

• Buckley Town – Bangor City · 23 jul 20211–0
• Bangor City – Buckley Town · 27 aug 20193–1