Also played on 4 Dec 2021

• Undy Athletic – Cwmbran Celtic3–4
• Llantwit Major – Briton Ferry0–1
• Port Talbot Town – Swansea University0–2
• Llanrhaeadr – Prestatyn Town3–2
• Trefelin – Carmarthen Town0–2
• Llandudno – Guilsfield0–0
• Ruthin Town – Penrhyncoch5–1
• Holyhead Hotspur – Airbus UK1–2
• Llanidloes Town – Holywell1–1

Previous meetings

2 earlier meetings: Bangor City won 1, 0 drawn, Buckley Town won 1.

• Buckley Town – Bangor City · 23 Jul 20211–0
• Bangor City – Buckley Town · 27 Aug 20193–1