| 1 mei 2027 | Southampton FC – Sheffield United FC | ––– | |
| 20 apr 2027 | Southampton FC – Birmingham City FC | ––– | |
| 10 apr 2027 | Southampton FC – Lincoln City FC | ––– | |
| 20 mrt 2027 | Southampton FC – Charlton Athletic FC | ––– | |
| 16 mrt 2027 | Southampton FC – Wolverhampton Wanderers F.C. | ––– | |
| 6 mrt 2027 | Southampton FC – Watford FC | ––– | |
| 20 feb 2027 | Southampton FC – Wrexham AFC | ––– | |
| 17 feb 2027 | Southampton FC – Norwich City FC | ––– | |
| 30 jan 2027 | Southampton FC – Preston North End FC | ––– | |
| 26 jan 2027 | Southampton FC – West Bromwich Albion FC | ––– | |
| 1 jan 2027 | Southampton FC – Cardiff City | ––– | |
| 29 dec 2026 | Southampton FC – West Ham United FC | ––– | |
| 19 dec 2026 | Southampton FC – Blackburn | ––– | |
| 9 dec 2026 | Southampton FC – Burnley FC | ––– | |
| 27 nov 2026 | Southampton FC – Middlesbrough FC | ––– | |
| 21 nov 2026 | Southampton FC – Derby County FC | ––– | |
| 31 okt 2026 | Southampton FC – Queens Park Rangers | ––– | |
| 17 okt 2026 | Southampton FC – Bolton Wanderers FC | ––– | |
| 11 okt 2026 | Southampton FC – Portsmouth FC | ––– | |
| 12 sep 2026 | Southampton FC – Bristol City FC | ––– | |
| 8 sep 2026 | Southampton FC – Swansea City | ––– | |
| 29 aug 2026 | Southampton FC – Millwall FC | ––– | |
| 22 aug 2026 | Southampton FC – Stoke City FC | 3–1 | |
| 25 mei 2025 | Southampton FC – Arsenal | 1–2 | |
| 10 mei 2025 | Southampton FC – Man City | 0–0 | |
| 26 apr 2025 | Southampton FC – Fulham FC | 1–2 | |
| 12 apr 2025 | Southampton FC – Aston Villa FC | 0–3 | |
| 2 apr 2025 | Southampton FC – Crystal Palace | 1–1 | |
| 15 mrt 2025 | Southampton FC – Wolves | 1–2 | |
| 22 feb 2025 | Southampton FC – Brighton & Hove Albion FC | 0–4 | |