Also played on 9 Mar 2022

• Irodotos – Egaleo3–0
• Larisa – Panserraikos–
• Levadiakos – Ergotelis–
• Veria – Almopos–
• Trikala – Iraklis 1908–
• Kallithea – Diagoras–
• Apollon Pontou – Niki Volos–
• Irodotos – AE Karaiskakis–
• Kifisia – Kalamata–
• OF Ierapetra – AEK Athens II–
• Thesprotos – PAOK II–
• Rodos – Kissamikos–

Previous meetings

5 earlier meetings: Apollon Larissa FC won 1, 3 drawn, Xanthi FC won 1.

• Xanthi FC – Apollon Larissa FC · 26 Jan 20220–0
• Xanthi FC – Apollon Larissa FC · 3 Mar 20210–0
• Apollon Larissa FC – Xanthi FC · 17 Jan 20211–1
• Xanthi FC – Apollon Larissa FC · 4 Dec 20193–0
• Apollon Larissa FC – Xanthi FC · 29 Oct 20192–1